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Some researchers have pointed out that dysregulation of lipid metabolism affects cellular sensitivity to ferroptosis ( Studies on hepatocellular carcinoma have revealed that activation of the oncogene BRCC36 promotes HMGCR deubiquitination, leading to its translocation from the plasma membrane to the endoplasmic reticulum ( + ) is an essential driver of ferroptosis, with iron uptake, storage, efflux, and transcriptional regulation collectively influencing iron homeostasis

Dual GLP-1 RA/gastric inhibitory polypeptide (GIP) : Similar to GLP-1 RA drugs, these medications can lead to significant weight loss in obese patients with or without type 2 diabetes

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However, the relevance to humans is uncertain