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16.1% on semaglutide Tirzepatide was superior on all five key secondary endpoints Gastrointestinal discontinuation rate was lower with tirzepatide (2.7%) than semaglutide (5.6%) These findings were consistent across all patient subgroups, regardless of sex, age, baseline BMI, or presence of metabolic comorbidities

Microscopic imaging and image analysis The immunostaining was imaged by using the upright THUNDER imaging system (Leica) with LAS X software (Leica)

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2EH), while triagonist therapy had no effects on glucose handling, but improved insulin sensitivity and reduced basal glucose levels (Fig