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Figure 6 Nuclear GSTP Inhibits HMGB1 Phosphorylation and Increases its DNA-Binding Affinity Classic protein kinase C has been reported to enter the nucleus and act as an upstream kinase of HMGB1 in LPS-stimulated macrophages and promotes HMGB1 to export from the nucleus to cytoplasm (7A, cPKC entered nucleus of RAW264.7 cells 20 min after LPS treatment, which was not prevented by overexpression of GSTP
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