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Fatigue Causes and Solutions If youre taking semaglutide or considering starting it, you might be wondering whether the medication will leave you feeling exhausted

Always start with the lowest recommended starting dose, even if you were on a high dose of tirzepatide, and increase the dose gradually to help your body adjust

But if you're still hungry on semaglutide, don't panic

Provide a history of previous treatments or lifestyle interventions youve tried and why they were insufficient

Sleep, Stress, and Hormones Research associates short sleep (under 7 hours) with higher levels of ghrelin (a hunger hormone) and lower levels of leptin (a hormone that signals fullness)