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Chiou HC, Lin MW, Hsiao PJ, Chen CL, Chiao S, Lin TY et al

Published pharmacokinetic studies show no direct interaction risk between these compounds, but concurrent use should align with overall treatment goals and biomarker context

doi: 10.1371/journal.pone.0094433 6 HainerVToplakHMitrakouA

doi:10.1002/mrd.23542

What does justify paying more: methylcobalamin over cyanocobalamin if you have confirmed MTHFR variants, higher methionine concentrations if baseline homocysteine is elevated, and the addition of L-carnitine if you have documented mitochondrial inefficiency or are combining Lipo C with a ketogenic protocol that depletes endogenous carnitine