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A prospective sequential treatment trial [66] in first episode patients has indicated that merely switching antipsychotics may not boost treatment response in early nonresponders, and second level treatments such as clozapine may be warranted even before the conventional clinical threshold of Treatment Resistant Schizophrenia (i.e., two treatment failures) is met
Pre-existing kidney disease requires medical supervision before supplementation
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221 In colorectal cancer, elevated EGFR ligand expression (e.g., AREG, EREG) sustains EGFRMAPK signaling and underlies resistance to EGFR-targeted therapies
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