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These limitations include fatigue, shortness of breath, reduced exercise capacity, and limb swelling

Given that PS on the cell surface may trigger several reactions, this abnormality may contribute to the erythrocyte pathology commonly encountered in chronic uremia, including ionic transport defects, osmotic alterations, deformations, fragility, and coagulation abnormalities

To assess cell viability, CellTiter-Glo (Promega) reagent was added according to the manufacturers instructions, and luminescence was measured using a microplate reader

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Related to the obstacle of crossing the BBB, any drug therapeutic efficacy depends on the administered intracellular dosage that effectively reaches the desired brain area