By targeting multiple pathways simultaneously, these agents may outpace traditional monotherapies in both efficacy and safety
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A Phase 2 randomised controlled trial published in the New England Journal of Medicine (Jastreboff et al., 2023) reported mean placebo-adjusted weight reductions of up to approximately 24% over 48 weeks in adults with obesity
Additionally, ferroptosis activates immune cells, particularly macrophages and microglia, by inducing inflammatory responses, playing a significant role in CNS pathology
This article was financially supported by National Institutes of Health Public Health Service grants R01 HL144790, R01 HL151493, R01 AI145813, R01 AI169687, R01 HL151769, and R01 HL159804 (OA)