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Loading, then maintenance Because B12 is water-soluble, the body doesnt bank large reserves it uses what it needs and clears the rest

Refrigeration is documented as a way to reach the full 28-day window reliably, not to push past it

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The practical consequences are two: the ascorbic acid degrades rapidly, losing its antioxidant and collagen-synthesis signaling value before it can act, and the superoxide generated in the process is a reactive oxygen species that may cause irritation or oxidize other formula components

doi: 10.1016/j.tcb.2020.09.006 43 LeeJHPhelanPShinMOhBCHanXImSSet al