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Pharmacies, prescribers, and regulators evaluate the final action, effective dates, interim policy, state requirements, and product-specific conditions
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Lactate promotes lactic acidification of histone H4 lysine 12 (H4K12la) by downregulating histone lysine delactase, inducing the enrichment of H4K12la in the SASP promoter region and SASP transcriptional activation to promote VSMC senescence
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