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Reports that DPP-4 may be associated with glucagon in the secretory granules of the pancreatic -cell first emerged in 1993, when positive staining in pig islets was shown using immunohistochemical and enzyme histochemical techniques (96), but the pancreatic localization of DPP-4 has also been unequivocally demonstrated more recently using molecular biological techniques (9799)

And I'll say, reading the book doing all the sort of thinking and research about GLP-1s and then reading the book kind of felt like reading a book from another era

doi:10.1001/jamapediatrics.2017.1919

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