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NICE guidance on metformin use recommends measuring B12 levels in patients with symptoms suggestive of deficiency

Obesity, insulin resistance, and chronic hyperglycaemia are all associated with increased inflammation and oxidative stress, which can negatively impact brain function

The microbes in your gut produce enzymes that break down complex compounds in food, allowing them to be absorbed more efficiently by the body

But side effects are very under-reported. About half of adults who start GLP-1s stop within a year some because their insurance coverage changes with many reporting gastrointestinal side effects as a contributor