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That is the evidence gap, stated plainly: the mechanism is well-motivated and the preclinical signal is consistent, but no human study has confirmed that any of it translates to people, at any dose, by any route
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Worsening neurological symptoms : Progressive weakness, worsening balance problems, or deteriorating cognitive function despite treatment requires urgent assessment
If your goal is addressing a B12 deficiency, a B12 shot may be appropriate on its own
Why Vitamin B12 Is Important Though it may take years for deficiency to develop in those starting out with adequate stores of vitamin B12, the results of B12 deficiency may include a magnitude of devastating physical and psychiatric symptoms, including death
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