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For instance, cocaine upregulates miR-212/132 in the striatum, which feeds back via CREB, MeCP2 and BDNF to limit cocaine reinforcement 180

Moreover, NAMPT activity is crucial for the beneficial effects of calorie restriction, including improved oxidative stress management, mitochondrial biogenesis, and metabolic adaptation, as reported in a study involving Sprague-Dawley rats 213

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