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reported side effects include: headache hypertension Drug Interactions: may cause hypertension if given with other pressor agents References: Biaggioni I (2021): Adrenoceptor Agonists & Sympathomimetic Drugs (Chapter 9)
In contrast, CHMP1A haploinsufficiency greatly exacerbated FA- or cisplatin-induced AKI by promoting ferroptosis through iron accumulation [177]
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Furthermore, a similar results were reported in a study of individuals with or without oligozoospermic which showed no significant association between DNA methylation in spermatozoa and the MTHFR C677T genotypes although a trend for higher incidence of methylation alterations in severe oligozoospermic infertile men with CT genotypes were observed 34 , suggesting that a much more complicated or indirect interactions between MTHFR polymorphism and methylation are involved
Cisplatin is one of the most efficacious, and, although its use produces several side-effects, it is still a drug of choise for treating a number of solid cancer 74,75
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