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As a non-neoplastic proliferative response, increased hepatocyte mitoses (Figure 92 ) above normal background levels or increased above what is seen in control animals can occur in rodent livers

Campfield, L

Contraindications and precautions Consider avoiding DSIP or consulting a physician if: Pregnant or breastfeeding (insufficient safety data) Taking naloxone or other opioid antagonists (may block effects) Using medications metabolized by peptidases (potential interactions) History of immune disorders (theoretical immunogenicity concern) Already using multiple sleep medications Drug interactions Because DSIP degrades via amino-peptidases in blood, medications affecting these enzymes (like the ACE inhibitor captopril) could theoretically alter DSIP metabolism

J Toxicol Pathol 22, 1133