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The serendipitous discovery of exendin-4 led to the development of exenatide immediate-release (exenatide IR, Byetta), a synthetic version of exendin-4 with C-terminal amidation to enhance its stability [ Figure 2 , Table 1 ], which became the first FDA-approved GLP-1RA in 2005 for the treatment of T2DM in adults [ Table 2 ]

Cloudiness indicates protein aggregation or particulate contamination, both of which render the peptide biologically inactive and potentially harmful

Cisplatins efficacy in liver cancer is limited by resistance and toxicity, but morin hydrate acts as a potent adjuvant to overcome these barriers

See the dedicated recovery dos and donts for the full list

Glutathione reductase enzyme converts the oxidized form of glutathione to the reduced and biologically active reduced form (GSH)