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Particularly noteworthy is that in patients with both type 2 diabetes and MASLD, after 24 weeks of treatment with a 10 mg dose of efinopegdutide, liver fat content reduced by 72.7%, a result that is superior to the 42.3% reduction achieved with a 1 mg dose of semaglutide, despite a similar overall weight loss being observed with the two interventions

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if confirmed, treatment should not be restarted

GLP-1 Receptor Activation: Increases insulin release, suppresses glucagon production, and promotes satiety

Cystine starvation promotes a non-canonical function of the glutathione synthesis machinery NRF2-mediated metabolism also promotes cell survival