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This study adds to the growing body of evidence supporting the pleiotropic effects of GLP-1 receptor agonists on cancer prevention, Lindsey Wang, an undergraduate student in the pre-professional scholars program at Case Western Reserve University, told Healio

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However, DPP-4 inhibitors have not reduced the risk of major adverse cardiovascular events, possibly because potentiation of SDF-1 enhances plaque growth and instability, activates deleterious neurohormonal mechanisms, and promotes cardiac inflammation and fibrosis

Additionally, prolonged use of these medications can lead to dependence, which is a significant concern for both patients and healthcare providers

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