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Latent TGFbeta complexes are transglutaminase cross-linked to fibrillin to facilitate TGFbeta activation
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Early Treatment Diabetic Retinopathy Study Research Group
Key Takeaways: Section 1 Patent filing fees of $10,000-$50,000 represent the visible portion of a cost structure that includes billions in capitalized R&D, multi-year international prosecution, and potential eight-figure litigation defense
This ERMCS-localised GLP-1R signalling hub requires the engagement of the AKAP SPHKAP, with VAPB playing a central role as the tethering factor responsible for the separate recruitments of both GLP-1R and SPHKAP to ERMCSs, the latter via the direct interaction of VAPB with the pFFAT motif of SPHKAP
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