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The acute form of the disease is characterized by the sudden onset of cardiac insufficiency, while the chronic form results in moderate-to-severe heart enlargement with varying degrees of cardiac insufficiency (52)

Drugs were applied for 1 min with a gravity-fed system

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Conclusion: Novel systemic therapies including Sint-IBI305 and Cam-Rivo demonstrated promising results compared to the current standard regimens (sorafenib, lenvatinib, and Atezo-Bev)