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It often causes sharp pain during or after a bowel movement, while internal hemorrhoids more often cause painless bleeding
A 2024 retrospective analysis suggested no significant excess of kidney stones with GLP-1 use, though long-term data is still accumulating
Governments looking to reduce the costs of healthcare and boost economic productivity also need to tread carefully when encouraging the use of GLP-1 drugs in people with obesity without addressing the wider socio-economic challenges patients face as well as the problems posed by the rise in ultra-processed food and poor provision of physical exercise facilities
What was filed is CagriSema (a fixed-dose combination pen of cagrilintide 2.4 mg plus semaglutide 2.4 mg), submitted to the FDA on 18 December 2025, with a review expected during 2026
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