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GLP-1R is expressed in the hypothalamus, brainstem, and reward circuits, where its activation reduces food intake through both satiety signalling and nausea pathways

The compound has been studied in trials lasting up to 68 weeks, which provides useful medium-term data but leaves questions about effects beyond 2 years of continuous use

Tesamorelin arrived later and was engineered for a different purpose entirely: a durable, degradation-resistant GHRH analog aimed at the metabolic problem of visceral fat accumulation in people with HIV on antiretroviral therapy

ArticlePubMed 89