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Melatonin's affordability makes it an accessible first-line option for most patients, while DSIP's higher cost may limit its use to patients who have failed standard treatments or specifically require enhanced deep sleep recovery
The risk of injecting degraded or contaminated peptide is not worth the cost savings of squeezing a few more doses from an old vial
Dose-by-dose weight loss in Phase 2 (NEJM) Phase 2 NEJM weight loss by dose, 24 and 48 weeks Dose 1 mg 24 weeks -7.2% 48 weeks -8.7% Dose 4 mg 24 weeks -12.9% 48 weeks -17.5% Dose 8 mg 24 weeks -15.7% 48 weeks -22.8% Dose 12 mg 24 weeks -17.5% 48 weeks -24.2% Dose Placebo 24 weeks -1.6% 48 weeks -2.1% Source: Jastreboff et al., NEJM 2023
10, e2002043
Nature 508 (7495), 258262
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