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GLP-1 receptor agonist intolerance refers to a situation where side effects become severe enough that a patient cannot continue treatment comfortably

For the primary composite endpoint of myocardial infarction, stroke or all-cause mortality, benchmarking identified high agreement between the reference trials and their emulations for all individual endpoints except for all-cause mortality in SUSTAIN-6, informing subsequent analyses

This is an area where policy details matter

[19] [20] However, existing NICE guidance on the management of obesity and type 2 diabetes including guidance on approved GLP-1 receptor agonists provides a relevant framework for understanding how such agents are evaluated and monitored within the NHS

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