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408 Preclinical and clinical research has shown metformin use is associated with improved endothelial function, lower levels of tissue factor, reduced levels of oxygen free radicals, and decreased platelet activation and aggregation
110,111 Causes of ER expression loss include epigenetic regulation, hypoxia, overexpression of epidermal growth factor receptor (EGFR) or human epidermal growth factor receptor 2 (HER2), and dysregulation of tumor suppressors such as p53 and pRb2/p130
Friedmans philosophy is that compounded pharmacies are supplying Tirzepatide and Semaglutide and not Ozempic, Wegovy, Zepbound and Mounjaro and that they are supplying customized dosing that are not available with the fixed doses supplied by the pharmaceutical companies
Supplements including turmeric/curcumin, fiber, cinnamon, and ginseng are believed to help lower blood sugar
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