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Gustafsson C, Mjsberg J, Matussek A, et al
Multiple signaling pathways are involved in the release of EVs
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Members of the Bcl-2 protein family are regulated through pathways influenced by estradiol, such that tumour cell expression of oestrogen receptors directly controls Bcl-2 levels (55, 56) Bcl-2-associated athanogene-1 (Bag-1), a Bcl-2-associated athanogene, functions as an anti-apoptotic protein by interacting with Bcl-2
It is an investigational drug in clinical trials
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