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Conversely, in glioblastoma, inhibition of HSP60 increases mitochondrial ROS generation, triggering AMPK activation and suppressing mTORC1-mediated phosphorylation of S6K and 4EBP1
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As a result, age-related retinal degeneration may be reversed in the older subjects, which is supported by the positive clinical outcome in 90% of the subjects presented with the peptide
PMID 26213263
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