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This is not a situation where standard doses of both drugs get prescribed without modification
18 Figure 14: PIONEER 10 trial design Source: Clinical Study Report
Starting with a lower dose and gradually increasing over several weeks, called titration, significantly reduces the severity and duration of side effects for most patients
A total of 85 healthy women, aged 4365 years old, were randomly assigned to the collagen group ( n = 42), which received supplementation of 5 g daily, or the placebo group ( n = 43) for 12 weeks
Tirzepatide increases by the same amount each time (2.5 mg steps), which makes escalation predictable
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