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The gut microbiome generates short-chain fatty acids, and butyrate in particular, from precursors such as lactate, succinate, certain amino acids, and carbohydrates (164167)

To date, 22 participants have been treated in the REVEAL-1 Cohort and are included in safety analyses, with 6-month follow-up efficacy data reported for 17

Key findings (Vafaei et al., 2025): 30-50 mg/kg mirtazapine: dose-dependent seizure suppression Mediated by CB1/CB2 activation (proven by antagonist blockade) GABA-independent mechanism (distinct from benzodiazepines) Appetite/weight gain provides in-vivo functional validation of CB1 engagement The broader implication: Clinicians and researchers have been using ECS pharmacologyunknowinglyfor decades