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Bayesian colocalization and multivariable Mendelian randomization (MVMR) analyses were conducted as supplementary analyses
The study found that this pathway begins with the activation of c-Jun-N-terminal kinase 1 (JNK1) and increased receptor-interacting protein 1 levels (RIP-1)
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Higher doses often yield stronger efficacy but also greater gastrointestinal issues, tolerability drop-outs, etc
Glucagon-like peptide-1 (GLP-1) is a naturally occurring incretin hormone produced primarily by specialised L-cells in the distal small intestine and colon
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