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Jumping straight to a high dose is a recipe for severe nausea, vomiting, and potentially abandoning the protocol altogether
Thats why the slow, steady dose increases were so reassuring
That matters, because it suggests the drinking effect is not simply a byproduct of losing weight
Canagliflozin's CREDENCE trial showed the strongest kidney-specific evidence for any SGLT2 inhibitor at the time of publication, with a 34% reduction in end-stage kidney disease alone (HR 0.68, P=0.002) [11]
ArticlePubMed 18
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