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Gler found that a new class of oral GLP-1 drugs can directly influence brain circuits tied to reward and motivation, not just hunger, meaning they have the ability to reshape not just appetite but the desire for food itself an effect that could help explain both the drugs success and their more puzzling side effects

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The GLP-1 revolution: Obesity drugs set to dominate next 50 years of medicine Experts provided comprehensive insights into three drugs reshaping longevity medicine: Metformin, semaglutide, and tirzepatide

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