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135 Cytokines such as TGF- and IL-6 further enforce these adaptations by reshaping the immune and metabolic landscape

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Solutions: Swirl gently (don't shake vigorously) Let sit 5-10 minutes Roll between palms gently If still won't dissolve, may be old or degraded (contact vendor) Prevention: Add water slowly down side of vial Use room temperature bacteriostatic water Don't inject directly onto powder pellet Injection site reactions Problem: Redness, swelling, or bump at injection site