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Tobaiqy, M
Clinical Trial Results: Weight Loss & Key Outcomes Phase 2 (Published in NEJM & Nature Medicine) Obesity trial (NEJM 2023): Up to 24.2% mean weight loss at 48 weeks (12 mg dose)
They work harmoniously because metformin targets cellular insulin resistance, while tirzepatide targets gut hormone receptors in the pancreas and brain
It's about your cells getting overloaded trying to process everything
In people with documented B12 deficiency, the association with depressive symptoms and anxiety is strong and well replicated
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