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Integrin subunits consist of an extracellular domain that is important for their ligand binding properties and contains a transmembrane domain and a short cytoplasmic tail, which could interact with diverse cytosolic and transmembrane proteins by consisting a focal adhesion complex (with the exception of 4) (Pozzi and Zent, 2003)

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1,2 The dose-by-dose data from the published trials: TRIUMPH-4s 18.2% discontinuation rate at 12 mg is more than three times higher than TRANSCEND-T2D-1s 5.1% on the same dose