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Advise patients to discontinue JANUMET immediately and to promptly notify their healthcare provider if unexplained hyperventilation, myalgias, malaise, unusual somnolence or other nonspecific symptoms occur

The piperidine ring (yellow) proved optimal in structure-activity relationship (SAR) studies, although other 6-membered rings (e.g., piperazine, cyclohexane) also demonstrated GLP-1R agonism

He Z, Zhang H, Li X, Tu S, Wang Z, Han S, et al

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