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Sleep-focused rationale: Addressing sleep disruption may provide foundational improvement enabling other interventions to work better

inhibition has been shown to reduce adipose mass in diet-induced obese mice

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Given the safety, relative low cost, and significant affect cobalamin deficiency can have on quality of life, we recommend B12 supplementation for all emaciated patients, regardless of whether access to serum cobalamin testing is available

The rationale for B12 inclusion is identical, though semaglutide lacks the GIP receptor component