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Plant-derived inhibitors obtusilactone A and sesamin effectively block LONP1 proteolytic function by forming hydrogen-bond networks with serine 855 and lysine 898 residues in its active site, thereby inducing apoptosis in lung cancer cells [141]
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GLP-1RAs appear to exert dual therapeutic benefits by concurrently ameliorating neuronal and vascular pathologies through stabilization of the BRB and suppression of inflammation-driven angiogenesis
Belanger M, Allaman I, Magistretti PJ
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