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Regarding the common effect of smoking on periodontitis, we reported previously higher mean PD (2.9 0.4 mm) and mean CAL (3.2 0.9 mm) in ever smokers compared to never smokers (PD 2.6 0.2 mm, P = 0.002 and CAL 2.8 0.3 mm, P = 0.015)
Taking capsules with a small amount of food is a reasonable practical choice to reduce gastric acid exposure slightly
Patients who notice no effect by day 7 are unlikely to benefit from continued injections without addressing other metabolic factors
Medication choices are not automatic and depend on screening
McCall KL, Mastro Dwyer KA, Casey RT
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