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Metformin-induced vitamin B12 deficiency can cause or worsen distal symmetrical, autonomic and cardiac neuropathy in the patient with diabetes

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therefore, it does not appear to trigger diabetes development or induce glucose intolerance in test models, though further studies are necessary to explore this aspect

NAD+ & Metabolic Pathways Because NNMT consumes nicotinamide, research investigates how its inhibition influences intracellular NAD+ salvage and methyl-donor balance