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FDA labeling for semaglutide notes that delayed gastric emptying may reduce absorption of orally administered medications

Once set, plugs were dehydrated through a serial ethanol gradient and HistoChoice (Sigma) before paraffin embedding with the Histoembedder station (Leica) and cutting to 1 m sections with a Leica Jung RM2035 microtome

Studies found it doesnt reduce the effectiveness of the combined pill to a clinically meaningful degree, so no extra precautions are needed

It is injected under the skin twice a day, within 60 minutes before the morning and evening meals, and it is not taken after a meal

The composition of the simulated systems is detailed in Supplementary Table S10