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GLP-1 receptor activation also suppresses glucagon secretion, slows gastric emptying, and promotes satiety through central nervous system pathways

Marguet D, Baggio L, Kobayashi T, Bernard AM, Pierres M, Nielsen PF, Ribel U, Watanabe T, Drucker DJ, Wagtmann N (2000) Enhanced insulin secretion and improved glucose tolerance in mice lacking CD26

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Typical side effects include nausea, vomiting, diarrhea, and constipation, which are generally mild and tend to diminish after a few weeks of treatment