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Multiple metabolic pathways contribute to reactive oxygen species generation, including increased mitochondrial flux, polyol pathway activation, protein kinase C signaling, and AGE formation itself [1416]

Since obesity is a major driver of type 2 diabetes, the resulting weight loss from reduced food consumption made GLP-1 agonists a double winner for diabetes-fighting

The assertion appears in a great many reviews and secondary articles, usually without a citation to a primary determination, and the primary measurements it ultimately rests on are few, old, and made with methods that predate current analytical practice for quantifying small peptides in plasma

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