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En cuanto a su farmacologa experimental, la inhibicin de NNMT y la consiguiente alteracin del eje NAD+/SAM son efectos que se estudian de forma controlada en modelos, sin que ello implique inferencias sobre efectos en organismos humanos
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Substantial epidemiological evidence has linked chronic exposure to environmental endocrine disruptors to a range of adverse reproductive outcomes in humans, including impaired spermatogenesis in males, diminished ovarian reserve in females, and an increased risk of infertility [100, 101]
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