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The term has emerged in media coverage and online communities as a label for retatrutide, a nextgeneration injectable designed to activate three different hormone receptors involved in metabolism: GLP1 (glucagonlike peptide1) GIP (glucosedependent insulinotropic polypeptide) Glucagon The logic behind the nickname is simple: Older drugs such as semaglutide (Ozempic, Wegovy) mainly target GLP1 (single agonist)
2014;8(262275):e9
Alternative pharmacological options include switching to a different FDA-approved weight management medication, as individual response varies between agents
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