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Intra-arterial administration also requires monitoring for thromboembolism and microvascular obstruction [48]

PMID: 19952320

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For instance, IL-1 can increase iron uptake and decrease GPX4 expression, thereby promoting ferroptosis

For researchers, the relevant cautions are (a) most of this work comes from a small number of laboratories with overlapping authorship across decades, and (b) the in vitro concentrations at which effects are reported (sub-nanomolar to nanomolar) are within the plasma-concentration range claimed for endogenous GHK, but human plasma concentrations themselves rest on a thin measurement base