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In cholangiocarcinoma, combined BET degradation and mTOR inhibition synergistically reduce acetylation of PSAT1-associated H3K27, inducing PSAT1 downregulation and subsequent dysfunction of the serine-glycine-one-carbon (SGOC) pathway (114)

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The difference between a vial containing a cloudy, gelled substance and one with a clear reconstituted compound can often be traced back to these subtle variations in BAC water composition