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Follow the dosage escalation below to reduce the risk of gastrointestinal adverse reactions [see Warnings and Precautions (5.7), Adverse Reactions (6.1)]

The peptide bonds that give semaglutide its appetite-suppressing and metabolic effects begin to break down in heat, typically above 25C (77F) for extended periods

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Similarly, GLP1-RA exenatide once weekly for 26 weeks reduced brain response, as measured by functional magnetic resonance imaging (fMRI), to alcohol cues in the ventral tegmental area 19