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The mechanism of action involves binding to both GIP and GLP-1 receptors, which stimulates insulin secretion in a glucose-dependent manner, suppresses glucagon release, and promotes satiety
Using both together can sometimes cause low blood sugar, so careful monitoring is needed
First, semaglutide needs to be kept within a specific temperature range to remain stable and effective
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In eye diseases like DR, high blood glucose and oxidative stress activate the Notch1-Hes signaling pathway, leading to ECM imbalance and promoting vascular dysfunction, inflammation, and retinal damage (Fan et al., 2020)
